Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 14/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.66 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.59 |
| ▸ | WNT3A | P56704 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493028 | 0.87 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11177667 | 0.85 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7971819 | 0.83 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1493038 | 0.83 | PSEN1 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11173851 | 0.83 | PIP4K2A (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492870 | 0.82 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12442177 | 0.82 | PORCN (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27809666 | 0.81 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492860 | 0.81 | CNR1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1780926 | 0.81 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-4376775-A | N-[4-(4-Pyridinyl)phenyl]ureas and their cardiotonic use | STERLING DRUG INC. (US) | 1983-03-15 | — | — | US | disclosed |