Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.38 |
| ▸ | TNF | P01375 | 6/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.38 |
| ▸ | HCK | P08631 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | MUSK | O15146 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968631 | 0.81 | MAPK14 (0.48) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL1619962 | 0.69 | MAPK14 (0.59) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL1619959 | 0.66 | MAPK14 (0.69) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL12277613 | 0.61 | MAPK14 (0.54) | MAPK14TNFMAPK12HCKSRC | |
| SCHEMBL29593381 | 0.60 | MAPK14 (0.76) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL296487 | 0.60 | MAPK14 (0.76) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL20876925 | 0.60 | MAPK14 (0.76) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL5306366 | 0.60 | MAPK14 (0.55) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL295776 | 0.59 | MAPK14 (0.70) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL29593878 | 0.59 | MAPK14 (0.70) | MAPK14TNFMAPK12HCKMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319921-B1 | FOR TREATMENT OF RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, GUILLAIN-BARRE SYNDROME, CROHN'S DISEASE ULCERATIVE COLITIS, PSORIASIS, GRAFT VERSUS HOST DISEASE, SYSTEMIC LUPUS ERYTHEMATOSUS AND DIABETES | BOERHINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-11-20 | — | — | US | claimed |