Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | EBP | Q15125 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956116 | 0.96 | SIGMAR1 (0.43) | SIGMAR1EBPMTORPTGESUBE2M | |
| SCHEMBL7958075 | 0.94 | SIGMAR1 (0.44) | SIGMAR1EBPMTORPTGESUBE2M | |
| SCHEMBL7956706 | 0.91 | SIGMAR1 (0.45) | SIGMAR1EBPTMEM97MEN1KMT2A | |
| SCHEMBL7969252 | 0.90 | SIGMAR1 (0.47) | SIGMAR1EBPMTORPTGESUBE2M | |
| SCHEMBL7966574 | 0.89 | EBP (0.54) | SIGMAR1EBPMEN1KMT2ASLC6A4 | |
| SCHEMBL7967345 | 0.89 | SIGMAR1 (0.43) | SIGMAR1EBPMTORPTGESUBE2M | |
| SCHEMBL7971835 | 0.89 | SIGMAR1 (0.45) | SIGMAR1EBPUBE2MDCUN1D1TMEM97 | |
| SCHEMBL7971832 | 0.89 | SIGMAR1 (0.45) | SIGMAR1EBPPTGESUBE2MDCUN1D1 | |
| SCHEMBL7966973 | 0.87 | SIGMAR1 (0.47) | SIGMAR1EBPMTORPTGESUBE2M | |
| SCHEMBL7971830 | 0.87 | EBP (0.43) | SIGMAR1EBPMEN1KMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265439-B1 | Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives | G.D. SEARLE & CO. | 2001-07-24 | — | — | US | disclosed |
| US-5451604-A | Useful in organ transplant surgery | G. D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |