Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | C3AR1 | Q16581 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968954 | 0.92 | HTR1A (0.42) | MEN1KMT2ADRD4HTR1ADRD3 | |
| SCHEMBL6177540 | 0.87 | MEN1 (0.46) | MEN1KMT2ADRD4HTR1ADRD3 | |
| SCHEMBL6176842 | 0.85 | DRD4 (0.63) | MEN1KMT2ADRD4HTR1ADRD3 | |
| SCHEMBL28746727 | 0.84 | KMT2A (0.49) | MEN1KMT2ADRD4HTR1ADRD3 | |
| SCHEMBL6180581 | 0.83 | MEN1 (0.53) | MEN1KMT2ADRD4CHRM4DRD2 | |
| Cyclohexane SCHEMBL6179896 | 0.80 | MEN1 (0.57) | MEN1KMT2ADRD4HTR1ACHRM4 | |
| SCHEMBL6178285 | 0.79 | MEN1 (0.55) | MEN1KMT2ADRD4HTR1ACHRM4 | |
| SCHEMBL6180578 | 0.79 | MEN1 (0.50) | MEN1KMT2ADRD4CHRM4DRD2 | |
| Cyclohexane SCHEMBL6178387 | 0.78 | MEN1 (0.48) | MEN1KMT2ADRD4HTR1ACHRM4 | |
| SCHEMBL6178420 | 0.78 | HTR1A (0.54) | MEN1KMT2AHTR1ACHRM4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239126-B1 | ANTAGONISTS OF THE 5HT1A RECEPTOR SUBTYPE. | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-29 | — | — | US | claimed |
| US-6239126-B1 | ANTAGONISTS OF THE 5HT1A RECEPTOR SUBTYPE. | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-29 | — | — | US | disclosed |