Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30011310 | 0.89 | GAA (0.83) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL22326350 | 0.87 | GAA (0.88) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL6570943 | 0.83 | GAA (0.74) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL24507059 | 0.82 | GAA (0.71) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL12029057 | 0.82 | GAA (1.00) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL12028883 | 0.82 | GAA (1.00) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL3077457 | 0.82 | GAA (1.00) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL13545621 | 0.81 | GAA (0.69) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL2452322 | 0.80 | GAA (0.69) | GAAALDH1A1CYP1A2RECQLKMT2A | |
| SCHEMBL6625137 | 0.80 | GAA (0.69) | GAAALDH1A1CYP1A2RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271357-B1 | REACTING SYNTHON WITH HYDRAZINE MOIETY WITH A SYNTHON HAVING ALDEHYDE MOIETY TO FORM COMPOUNDS THAT MIMIC OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| US-6121433-A | FOR DIAGNOSTIC, RESEARCH AND THERAPEUTIC USE; MIMIC OR MODULATE PROTEINS, ENZYMES, NUCLEIC ACIDS AND LIPIDS | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0746326-A4 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS INC (US) | 2000-06-14 | — | — | EP | disclosed |
| US-5783682-A | Oligonucleotide mimics having nitrogen-containing linkages | ISIS PHARMACEUTICALS, INC. (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0746326-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995018623-A1 | OLIGOMERIC COMPOUNDS HAVING NITROGEN-CONTAINING LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |