Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 9/20 | 0.65 |
| ▸ | ACE | P12821 | 6/20 | 0.63 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | PREP | P48147 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786158 | 1.00 | FKBP1A (0.65) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6786152 | 1.00 | FKBP1A (0.65) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6793620 | 0.95 | FKBP1A (0.62) | FKBP1AACE | |
| SCHEMBL6786208 | 0.95 | FKBP1A (0.62) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6786218 | 0.95 | FKBP1A (0.62) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6793612 | 0.95 | FKBP1A (0.62) | FKBP1AACE | |
| SCHEMBL6787342 | 0.95 | FKBP1A (0.62) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL9097059 | 0.94 | FKBP1A (0.61) | FKBP1AACE | |
| SCHEMBL6784238 | 0.94 | FKBP1A (0.61) | FKBP1AACEKLK7KLK5 | |
| SCHEMBL6784258 | 0.94 | FKBP1A (0.61) | FKBP1AACEKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262089-B1 | USING THESE COMPOUNDS TO TREAT DISEASES ASSOCIATED WITH AMYLOIDOSIS, SUCH AS ALZHEIMER'S DISEASE, MATURITY ONSET DIABETES MELLITUS, FAMILIAL AMYLOID POLYNEUROPATHY, SCRAPIE, AND KREUZFELD-JACOB DISEASE. | HOFFMAN-LA ROCHE INC. | 2001-07-17 | — | — | US | disclosed |