Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.61 |
| ▸ | JAK2 | O60674 | 19/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL796964 | 0.85 | TYK2 (0.57) | TYK2JAK2 | |
| SCHEMBL14857954 | 0.84 | JAK2 (0.65) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372683 | 0.77 | TYK2 (0.62) | TYK2JAK2 | |
| SCHEMBL2385826 | 0.76 | JAK2 (0.75) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL791937 | 0.75 | TYK2 (0.87) | TYK2JAK2 | |
| SCHEMBL2371904 | 0.73 | TYK2 (0.52) | TYK2JAK2 | |
| SCHEMBL2371085 | 0.73 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL12295375 | 0.72 | JAK2 (0.62) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2384762 | 0.72 | PTGES (0.52) | TYK2JAK2 | |
| SCHEMBL2388178 | 0.72 | JAK2 (0.69) | TYK2JAK2JAK1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | claimed |