Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287292 | 0.96 | MEN1 (0.41) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL10287200 | 0.90 | MAPK1 (0.43) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL796373 | 0.87 | MAPT (0.42) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL796310 | 0.85 | MAPT (0.42) | MEN1KMT2AMAPTADORA2AALOX15 | |
| SCHEMBL794305 | 0.78 | KDM4E (0.53) | MEN1KMT2AMAPTLMNAALOX15 | |
| SCHEMBL15477225 | 0.75 | MAPT (0.50) | MEN1KMT2AMAPTLMNAALOX15 | |
| SCHEMBL795967 | 0.75 | NTRK1 (0.43) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL795592 | 0.73 | CTSL (0.42) | MEN1KMT2ATP53ALOX15TSHR | |
| SCHEMBL795741 | 0.72 | SMN1; SMN2 (0.43) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL796263 | 0.71 | SMN1; SMN2 (0.42) | MEN1KMT2AMAPTLMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |