SCHEMBL7969932

SCHEMBL7969932

COc1ccc(Cn2c(N)cc(=O)[nH]c2=O)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.76
MTNR1B P49286 1/20 0.76
ALDH1A1 P00352 6/20 0.71
MAPT P10636 4/20 0.71
KMT2A Q03164 3/20 0.71
MEN1 O00255 2/20 0.71
CYP3A4 P08684 1/20 0.68
HPGD P15428 1/20 0.68
KDM4E B2RXH2 3/20 0.54
CMA1 P23946 1/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
THRB P10828 1/20 0.51
TSHR P16473 1/20 0.50
TYMS P04818 1/20 0.50
TLR7 Q9NYK1 1/20 0.49
PNP P00491 1/20 0.49
ALOX15 P16050 1/20 0.47
ATM Q13315 1/20 0.47
GRIN1 Q05586 1/20 0.46
GRIN2B Q13224 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1958423 0.86 GAA (0.59) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL8581842 0.86 KMT2A (0.70) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL9412479 0.84 ALDH1A1 (0.72) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL8576806 0.84 KMT2A (0.59) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL7679940 0.82 ALDH1A1 (0.77) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL1032784 0.82 HPGD (1.00) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL9412738 0.81 ALDH1A1 (0.67) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL7088588 0.78 ALDH1A1 (0.74) MTNR1AMTNR1BALDH1A1MAPTKMT2A
SCHEMBL4762572 0.78 ALDH1A1 (0.63) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL6093318 0.77 ALDH1A1 (0.56) MTNR1AMTNR1BALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187780-B1 ANTIDEPRESSANTS, ANTIASTHMATIC AGENTS; MIGRAINE BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-02-13 US disclosed
CN-1043348-C Asymmetrically substituted xanthines BOEHRINGER INGELHEIM KG (DE) 1999-05-12 CN disclosed
US-5719279-A CHOLINOMIMETICS BOEHRINGER INGELHEIM KG (DE) 1998-02-17 US disclosed
EP-0654033-A1 ASYMMETRICALLY SUBSTITUTED XANTHINE WITH ADENOSINE-ANTAGONISTIC PROPERTIES BOEHRINGER INGELHEIM KG (DE) 1995-05-24 EP disclosed
WO-1994003456-A1 ASYMMETRICALLY SUBSTITUTED XANTHINE WITH ADENOSINE-ANTAGONISTIC PROPERTIES BOEHRINGER INGELHEIM KG (DE) 1994-02-17 WO disclosed