Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970278 | 1.00 | KDM4E (0.43) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL7969153 | 0.83 | KDM4E (0.40) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL7969155 | 0.83 | KDM4E (0.40) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9219821 | 0.77 | POLB (0.39) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9219816 | 0.77 | POLB (0.39) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9270772 | 0.76 | KDM4E (0.40) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9270775 | 0.76 | KDM4E (0.40) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9209875 | 0.74 | RAB9A (0.63) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL23912944 | 0.74 | POLB (0.53) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL2645337 | 0.74 | RAB9A (0.49) | KDM4EMAPTRAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303641-B1 | FOR THERAPY AND PROPHYLAXIS OF DISEASES CHARACTERIZED BY ABNORMAL CELL DIFFERENTIATION AND/OR CELL PROLIFERATION SUCH AS PSORIASIS AND CANCER | LEO PHARMACEUTICALS PRODUCTS LTD. (DK) | 2001-10-16 | — | — | US | disclosed |
| JP-2000327662-A | PRODUCTION OF PYRIDINECARBOXAMIDINE COMPOUND | SUMIKA FINE CHEMICALS CO LTD | 2000-11-28 | — | — | JP | disclosed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0536424-A1 | NOVEL BENZOPYRAN DERIVATIVE | Japan Tobacco Inc. (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |