Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616599 | 0.87 | SLC22A12 (0.49) | SLC22A12KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7984640 | 0.87 | SLC22A12 (0.61) | SLC22A12PTGER4MEN1KMT2A | |
| SCHEMBL3604440 | 0.86 | SLC22A12 (0.43) | SLC22A12CNR2KDM4EMEN1KMT2A | |
| SCHEMBL31633052 | 0.86 | CNR2 (0.46) | CNR2CNR1PTGER4MERTKOPRD1 | |
| SCHEMBL3604441 | 0.84 | SLC22A12 (0.43) | SLC22A12CNR2CNR1PTGER4KDM4E | |
| SCHEMBL3597241 | 0.79 | SLC22A12 (0.43) | SLC22A12MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3597239 | 0.79 | SLC22A12 (0.43) | SLC22A12MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7981717 | 0.79 | MERTK (0.44) | SLC22A12CNR2CNR1MERTKKDM4E | |
| SCHEMBL3605146 | 0.79 | MERTK (0.46) | SLC22A12CNR2CNR1MERTKKDM4E | |
| SCHEMBL27272748 | 0.79 | SLC22A12 (0.44) | SLC22A12KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |