Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616599 | 0.90 | SLC22A12 (0.49) | SLC22A12MEN1KMT2AKDM4CP2RY14 | |
| SCHEMBL7970829 | 0.87 | SLC22A12 (0.47) | SLC22A12MEN1KMT2APTGER4 | |
| SCHEMBL3604441 | 0.83 | SLC22A12 (0.43) | SLC22A12MEN1KMT2APTGER4 | |
| SCHEMBL3597241 | 0.82 | SLC22A12 (0.43) | SLC22A12MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3597239 | 0.82 | SLC22A12 (0.43) | SLC22A12MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3604440 | 0.82 | SLC22A12 (0.43) | SLC22A12MEN1KMT2A | |
| SCHEMBL28772830 | 0.80 | SLC22A12 (0.39) | SLC22A12KDM4C | |
| SCHEMBL8358690 | 0.79 | PDE4A (0.59) | SLC22A12 | |
| SCHEMBL24975827 | 0.78 | SLC22A12 (0.46) | SLC22A12PTGER4KDM4C | |
| SCHEMBL7379307 | 0.78 | TEAD1 (0.53) | SLC22A12MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | claimed |
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |