Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797092 | 1.00 | MAPT (0.50) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL807793 | 1.00 | MAPT (0.50) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8416381 | 0.82 | KMT2A (0.64) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8416379 | 0.82 | KMT2A (0.64) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27683596 | 0.81 | MAPT (0.48) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8986616 | 0.79 | ALDH1A1 (0.52) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8758311 | 0.79 | ALDH1A1 (0.52) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL797979 | 0.79 | MAPT (0.72) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL797978 | 0.79 | MAPT (0.72) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL31236298 | 0.79 | MAPT (0.72) | MAPTKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |