Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | RECQL | P46063 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | CASP6 | P55212 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26768827 | 0.88 | NPSR1 (0.69) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26768834 | 0.88 | PKLR (0.53) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26768129 | 0.88 | KDM4E (0.54) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26779750 | 0.88 | NPSR1 (0.69) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26767072 | 0.88 | KDM4E (0.54) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL24922443 | 0.81 | NPSR1 (0.77) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL29466712 | 0.81 | NPSR1 (0.77) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL31408197 | 0.81 | NPSR1 (0.77) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26779758 | 0.81 | NPSR1 (0.77) | PKLRKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL26767068 | 0.81 | KDM4E (0.53) | KDM4ECYP3A4KMT2AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |