SCHEMBL7971103

SCHEMBL7971103

CCOC(=O)C1CC(c2ccc(F)cc2)C1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
TDP1 Q9NUW8 3/20 0.46
KMT2A Q03164 3/20 0.45
POLB P06746 3/20 0.45
MEN1 O00255 2/20 0.45
LMNA P02545 2/20 0.45
RECQL P46063 1/20 0.42
MAPT P10636 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KDM4E B2RXH2 2/20 0.40
TP53 P04637 1/20 0.40
GAA P10253 1/20 0.40
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7971105 1.00 ALDH1A1 (0.46) ALDH1A1TDP1KMT2APOLBMEN1
SCHEMBL2548786 0.86 ALDH1A1 (0.51) ALDH1A1TDP1KMT2APOLBMEN1
SCHEMBL16708942 0.86 ESR2 (0.52) ALDH1A1KMT2APOLBMEN1LMNA
SCHEMBL21065269 0.86 ESR2 (0.52) ALDH1A1KMT2APOLBMEN1LMNA
SCHEMBL9195822 0.84 MEN1 (0.51) ALDH1A1KMT2APOLBMEN1LMNA
SCHEMBL26580345 0.84 ALDH1A1 (0.48) ALDH1A1KMT2APOLBMEN1LMNA
SCHEMBL9195825 0.84 MEN1 (0.51) ALDH1A1KMT2APOLBMEN1LMNA
SCHEMBL11660640 0.84 TSHR (0.55) ALDH1A1KMT2AMEN1MAPTCYP1A2
SCHEMBL11660644 0.84 TSHR (0.55) ALDH1A1KMT2AMEN1MAPTCYP1A2
SCHEMBL7969817 0.84 ALDH1A1 (0.47) ALDH1A1TDP1KMT2APOLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068785-B1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-06-26 EP disclosed
EP-3068785-B1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-06-26 EP disclosed
US-6291520-B1 INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES PFIZER 2001-09-18 US disclosed
EP-0559743-B1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE PFIZER (US) 1995-03-08 EP disclosed
EP-0559743-A1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. PFIZER HOSPITAL PROD (US) 1993-09-15 EP disclosed
WO-1992009566-A1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE PFIZER INC. (US) 1992-06-11 WO disclosed