Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971261 | 1.00 | ALOX5 (0.47) | ALOX5SLC9A1HRH3ALDH1A1POLB | |
| SCHEMBL7970872 | 0.85 | ALOX5 (0.47) | ALOX5SLC9A1POLBTP53HTR2A | |
| SCHEMBL7970869 | 0.85 | ALOX5 (0.47) | ALOX5SLC9A1POLBTP53HTR2A | |
| SCHEMBL7975745 | 0.84 | ALOX5 (0.50) | ALOX5 | |
| SCHEMBL7975742 | 0.84 | ALOX5 (0.50) | ALOX5 | |
| SCHEMBL7969363 | 0.81 | ALOX5 (0.44) | ALOX5ALDH1A1POLBMAPK1GAA | |
| SCHEMBL7969361 | 0.81 | ALOX5 (0.44) | ALOX5ALDH1A1POLBMAPK1GAA | |
| SCHEMBL7971059 | 0.79 | ALOX5 (0.62) | ALOX5SLC9A1HTR2AHTR2CHTR2B | |
| SCHEMBL7971054 | 0.79 | ALOX5 (0.62) | ALOX5SLC9A1HTR2AHTR2CHTR2B | |
| SCHEMBL7976148 | 0.76 | ALOX5 (0.47) | ALOX5SLC9A1ALDH1A1POLBALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |