Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970587 | 0.92 | TOP1 (0.34) | ALDH1A1SMN1; SMN2HPGDHSD17B10TOP1 | |
| SCHEMBL7973155 | 0.92 | F9 (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7971678 | 0.91 | NPC1 (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7972135 | 0.91 | PDE10A (0.37) | SMN1; SMN2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL7970581 | 0.90 | F9 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7970061 | 0.90 | GUSB (0.39) | ALDH1A1SMN1; SMN2NPC1KDM4ERAB9A | |
| SCHEMBL10139961 | 0.90 | GUSB (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7960814 | 0.90 | NPC1 (0.39) | ALDH1A1SMN1; SMN2NPC1KDM4ERAB9A | |
| SCHEMBL7973095 | 0.89 | DHODH (0.36) | ALDH1A1SMN1; SMN2GAAHPGDHSD17B10 | |
| SCHEMBL7965824 | 0.88 | SIRT2 (0.37) | ALDH1A1SMN1; SMN2MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |