Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971397 | 0.91 | ALDH1A1 (0.39) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL7962296 | 0.90 | NPBWR1 (0.36) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL7972135 | 0.90 | PDE10A (0.37) | NPC1RAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL7971392 | 0.89 | SCD (0.42) | HPGDALDH1A1KDM4ETP53MAPT | |
| SCHEMBL7971418 | 0.89 | SCD (0.42) | GAAHSD17B2SCD | |
| SCHEMBL7971780 | 0.88 | FGFR2 (0.40) | CDK2PRKCZF7HSD17B2JAK2 | |
| SCHEMBL7971018 | 0.88 | HSD17B10 (0.37) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL7974911 | 0.87 | CHEK2 (0.43) | PRKCZ | |
| SCHEMBL7970587 | 0.87 | TOP1 (0.34) | HPGDALDH1A1SMN1; SMN2HSD17B10F10 | |
| SCHEMBL7973155 | 0.87 | F9 (0.39) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |