Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 8/20 | 0.45 |
| ▸ | MAOA | P21397 | 7/20 | 0.45 |
| ▸ | KDM1A | O60341 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19359197 | 0.82 | TSHR (0.61) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL19381183 | 0.82 | TSHR (0.61) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL4775523 | 0.82 | TSHR (0.61) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL1265897 | 0.80 | TSHR (0.48) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL12926851 | 0.80 | TSHR (0.48) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL1265896 | 0.80 | TSHR (0.48) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL1265899 | 0.80 | TSHR (0.48) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL14589045 | 0.80 | TSHR (0.48) | TSHRMAOBMAOAKDM1ACYP2C19 | |
| SCHEMBL16422345 | 0.80 | KDM1A (0.48) | TSHRMAOBMAOAKDM1ASLC6A2 | |
| SCHEMBL16423075 | 0.80 | KDM1A (0.48) | TSHRMAOBMAOAKDM1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1434485-B1 | NICOTINIC ACID-HETEROCYCLYL-AMIDES AND ANALOGOUS PYRIMIDINE DERIVATIVES FOR USE AS PESTICIDES | MERIAL LTD (US) | 2007-05-16 | — | — | EP | disclosed |
| US-6207668-B1 | FOR CONTROLLING INSECTS OR THEIR EGGS; AS FUNGICIDES, OVICIDES OR AS VETERINARY MEDICAMENTS | HOECHST SCHERING (DE) | 2001-03-27 | — | — | US | disclosed |
| EP-0892798-A1 | SUBSTITUTED PYRIDINES/PYRIMIDINES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF AS PESTICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997037991-A1 | SUBSTITUTED PYRIDINES/PYRIMIDINES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF AS PESTICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1997-10-16 | — | — | WO | disclosed |