Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 11/20 | 0.42 |
| ▸ | KDM1A | O60341 | 11/20 | 0.42 |
| ▸ | MAOA | P21397 | 9/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265897 | 1.00 | TSHR (0.48) | TSHRMAOBKDM1AMAOACYP2C19 | |
| SCHEMBL14589045 | 1.00 | TSHR (0.48) | TSHRMAOBKDM1AMAOACYP2C19 | |
| SCHEMBL12926851 | 1.00 | TSHR (0.48) | TSHRMAOBKDM1AMAOACYP2C19 | |
| SCHEMBL1265896 | 1.00 | TSHR (0.48) | TSHRMAOBKDM1AMAOACYP2C19 | |
| SCHEMBL29847437 | 0.81 | KDM1A (0.46) | MAOBKDM1AMAOATAAR1SLC6A2 | |
| SCHEMBL16422768 | 0.81 | KDM1A (0.46) | MAOBKDM1ASLC6A2SLC6A3HTR2C | |
| SCHEMBL16422767 | 0.81 | KDM1A (0.46) | MAOBKDM1ASLC6A2SLC6A3HTR2C | |
| SCHEMBL16422783 | 0.81 | KDM1A (0.46) | MAOBKDM1ASLC6A2SLC6A3HTR2C | |
| SCHEMBL1195857 | 0.81 | TSHR (0.64) | TSHRMAOBCYP2C19SLC6A2SLC6A3 | |
| SCHEMBL7971631 | 0.80 | TSHR (0.64) | TSHRMAOBKDM1AMAOACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212184-B1 | SUBSTITUTED BENZOTETRAHYDROPYRANS AND THEIR USE | ABBVIE OVERSEAS SARL (LU) | 2020-04-01 | — | — | EP | disclosed |
| EP-3212184-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | Abbvie S.a.r.l. (LU) | 2017-09-06 | — | — | EP | disclosed |
| US-9567322-B2 | Substituted tetrahydropyrans and method of use | ABBVIE S.Á.R.L. (LU) | 2017-02-14 | — | — | US | disclosed |
| WO-2016069891-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | ABBVIE INC. (US) | 2016-05-06 | — | — | WO | disclosed |
| US-20160122331-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | ABBVIE OVERSEAS S.Á.R.L. (LU) | 2016-05-05 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| US-7884109-B2 | immunosuppressants such as 2-(6-Fluoro-1H-benzo[d]imidazol-1-yl)-9-((1R,4R)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-7H-purin-8(9H)-one, used for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection | WYETH LLC (US) | 2011-02-08 | — | — | US | disclosed |
| CN-1823051-B | Process for producing 4-aminotetrahydropyran compound and acid salt thereof, intermediate for synthesis thereof, and process for producing the same | UBE INDUSTRIES | 2010-07-07 | — | — | CN | disclosed |
| US-20080287468-A1 | PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION | PHARMACOPEIA, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| US-7365215-B2 | Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same | UBE INDUSTRIES, LTD. (JP) | 2008-04-29 | — | — | US | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1434485-B1 | NICOTINIC ACID-HETEROCYCLYL-AMIDES AND ANALOGOUS PYRIMIDINE DERIVATIVES FOR USE AS PESTICIDES | MERIAL LTD (US) | 2007-05-16 | — | — | EP | disclosed |
| US-20070106083-A1 | Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same | UBE INDUSTRIES, LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| US-20070021443-A1 | Purine and imidazopyridine derivatives for immunosuppression | WYETH LLC | 2007-01-25 | — | — | US | disclosed |
| CN-1823051-A | Process for producing 4-aminotetrahydropyran compound and acid salt thereof, intermediate for synthesis thereof, and process for producing the same | UBE INDUSTRIES (JP) | 2006-08-23 | — | — | CN | disclosed |
| EP-1661894-A1 | PROCESS FOR PRODUCTION OF 4-AMINOTETRAHYDROPYRANS AND SALTS THEREOF WITH ACIDS, INTERMEDIATES FOR THE PROCESS, AND PROCESS FOR PRODUCTION THEREOF | Ube Industries, Ltd. (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021443-A1 | Purine and imidazopyridine derivatives for immunosuppression | TPMT, P2RY4, P2RY1 | TSHR 3899/4885MAOB 943/4885KDM1A 1830/4885 |
| US-20070106083-A1 | Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same | PAH, HPD, REN | TSHR 3997/4885MAOB 1072/4885KDM1A 1487/4885 |
| US-20160122331-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | CFTR, MRPL21, TACR1 | TSHR 285/4885MAOB 3077/4885KDM1A 4345/4885 |
| US-20080287468-A1 | PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION | TPMT, P2RY4, P2RY1 | TSHR 3899/4885MAOB 943/4885KDM1A 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.