Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210669 | 0.82 | TDP1 (0.64) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL1260097 | 0.81 | LMNA (0.48) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL6925882 | 0.81 | MAPT (0.44) | TDP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6654554 | 0.78 | TDP1 (0.70) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL248492 | 0.78 | TDP1 (0.70) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL5971482 | 0.75 | TDP1 (0.59) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL10004123 | 0.74 | TDP1 (0.64) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL11416304 | 0.74 | TDP1 (0.53) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL776223 | 0.72 | TDP1 (0.61) | TDP1ALDH1A1CES2CES1LMNA | |
| SCHEMBL11786927 | 0.72 | TDP1 (0.61) | TDP1ALDH1A1CES2CES1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294545-B1 | INSECTICIDES | SYNGENTA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-0944319-A1 | INSECTICIDAL COMPOSITIONS AND METHODS | ZENECA LIMITED (GB) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023158-A1 | INSECTICIDAL COMPOSITIONS AND METHODS | ZENECA LIMITED (GB) | 1998-06-04 | — | — | WO | disclosed |