Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prucalopride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 9/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.95 |
| ▸ | ACHE | P22303 | 1/20 | 0.95 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | HTR3A | P46098 | 1/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prucalopride SCHEMBL16952 | 0.97 | HTR4 (1.00) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL1230671 | 0.96 | HTR4 (0.98) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL7960440 | 0.96 | HTR4 (0.98) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL28260565 | 0.96 | HTR4 (0.98) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL7970517 | 0.96 | HTR4 (0.98) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL1230437 | 0.95 | HTR4 (0.92) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL27956868 | 0.95 | HTR4 (0.92) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL7426504 | 0.95 | HTR4 (0.95) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL7972080 | 0.94 | HTR4 (0.93) | HTR4HTR1AADRA2CACHEPTGS1 | |
| Prucalopride SCHEMBL27531479 | 0.94 | HTR4 (0.93) | HTR4HTR1AADRA2CACHEPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310077-B1 | ALKYLATING SUBSTITUTED BENZOFURANCARBOXAMIDE WITH 1-CHLORO-3-METHOXYPROPANE IN SOLVENT IN PRESENCE OF BASE OR ACYLATING 1-(3-METHOXYPROPYL)-4-PIPERIDINAMINE WITH SUBSTITUTED BENZOFURANCARBOXYLIC ACID, FORMING SALT IF DESIRED | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-10-30 | — | — | US | disclosed |