SCHEMBL7972134

SCHEMBL7972134

CC(=O)N1CCN(NC(=O)c2ccc(C)nc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.53
HDAC6 Q9UBN7 2/20 0.53
KDM4E B2RXH2 1/20 0.45
CYP2D6 P10635 2/20 0.43
GRM5 P41594 1/20 0.43
ALDH1A1 P00352 4/20 0.42
MAPT P10636 3/20 0.42
NPC1 O15118 1/20 0.42
VNN1 O95497 1/20 0.41
CYP2C9 P11712 2/20 0.40
HPGD P15428 2/20 0.40
CYP2C19 P33261 1/20 0.40
GAA P10253 1/20 0.40
CYP1A2 P05177 1/20 0.40
POLB P06746 1/20 0.40
CYP3A4 P08684 1/20 0.40
CHEK1 O14757 1/20 0.40
CYP19A1 P11511 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7972591 0.81 CYP2D6 (0.58) CYP2D6GRM5
SCHEMBL12083951 0.78 CKS1B (0.47) HDAC1HDAC6KDM4EALDH1A1NPC1
SCHEMBL7972839 0.78 CYP2D6 (0.53) HDAC6CYP2D6ALDH1A1MAPTNPC1
SCHEMBL8018069 0.78 CYP2D6 (0.53) HDAC6CYP2D6ALDH1A1MAPTNPC1
SCHEMBL194951 0.77 CYP2D6 (0.72) KDM4ECYP2D6ALDH1A1MAPTCYP2C9
SCHEMBL14590778 0.76 HTT (0.65) HDAC6CYP2D6MAPTNPC1CYP2C9
SCHEMBL7975154 0.76 HPGD (0.50) HDAC1HDAC6KDM4EALDH1A1MAPT
SCHEMBL7968909 0.75 CYP2D6 (0.50) CYP2D6ALDH1A1MAPTNPC1CYP2C9
Water SCHEMBL3089403 0.75 CYP2D6 (0.70) KDM4ECYP2D6ALDH1A1MAPTCYP2C9
SCHEMBL7972482 0.74 CYP2D6 (0.49) HDAC1HDAC6CYP2D6ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291464-B1 POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-09-18 US disclosed
EP-0968201-A2 NEW AMINOPIPERAZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-01-05 EP disclosed
WO-1998035951-A2 NEW AMINOPIPERAZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-08-20 WO disclosed