⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578465 | 0.80 | — | — | |
| SCHEMBL22231 | 0.78 | — | — | |
| SCHEMBL865941 | 0.73 | FDPS (0.31) | — | |
| SCHEMBL81194 | 0.72 | — | — | |
| SCHEMBL23176680 | 0.71 | — | — | |
| SCHEMBL1539335 | 0.69 | — | — | |
| SCHEMBL29260491 | 0.69 | FDPS (0.30) | — | |
| SCHEMBL8367425 | 0.69 | — | — | |
| SCHEMBL45743 | 0.69 | — | — | |
| SCHEMBL12236882 | 0.69 | FDPS (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759589-B | Pyrimidopyridinones and their use | 暨南大学 | 2022-04-08 | — | — | CN | claimed |
| CN-108218849-B | Novel inhibitors | 维沃永治疗公众有限公司 | 2022-03-01 | — | — | CN | claimed |
| CN-111315738-B | Inhibitors of glutaminyl cyclase | 维沃永治疗股份公司 | 2021-08-03 | — | — | CN | claimed |
| CN-112759589-A | Pyrimidopyridinones and their use | 暨南大学 | 2021-05-07 | — | — | CN | claimed |
| US-20200223825-A1 | INHIBITORS OF GLUTAMINYL CYCLASE | VIVORYON THERAPEUTICS N.V (DE) | 2020-07-16 | — | — | US | claimed |
| CN-111315738-A | Inhibitors of glutaminyl cyclase | 维沃永治疗股份公司 | 2020-06-19 | — | — | CN | claimed |
| EP-3461819-B1 | INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2020-05-27 | — | — | EP | claimed |
| EP-2970235-B1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2019-06-19 | — | — | EP | claimed |
| WO-2019063414-A1 | INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2019-04-04 | — | — | WO | claimed |
| EP-3461819-A1 | INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2019-04-03 | — | — | EP | claimed |
| EP-2970235-A1 | NOVEL INHIBITORS | Probiodrug AG (DE) | 2016-01-20 | — | — | EP | claimed |
| WO-2014140279-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2014-09-18 | — | — | WO | claimed |
| EP-2686313-A1 | BENZ IMIDAZOLE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2014-01-22 | — | — | EP | claimed |
| US-8530670-B2 | Inhibitors | PROBIODRUG AG (DE) | 2013-09-10 | — | — | US | claimed |
| US-20120237475-A1 | Novel Inhibitors | PROBIODRUG AG (DE) | 2012-09-20 | — | — | US | claimed |
| WO-2012123563-A1 | BENZ IMIDAZOLE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2012-09-20 | — | — | WO | claimed |
| US-8143408-B2 | N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | claimed |
| US-20100137322-A1 | NOVEL N-(8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N-(5-HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | US | claimed |
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | claimed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |