Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | NMBR | P28336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040511 | 0.99 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL3385872 | 0.90 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL4682017 | 0.89 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL4695670 | 0.88 | SIRT2 (0.46) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL1040962 | 0.84 | SIRT2 (0.46) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL5891927 | 0.84 | SIRT2 (0.46) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL7700148 | 0.81 | SIRT2 (0.43) | SIRT2NMBR | |
| SCHEMBL7700153 | 0.81 | SIRT2 (0.43) | SIRT2NMBR | |
| SCHEMBL7623008 | 0.81 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2NMBR | |
| SCHEMBL4382643 | 0.79 | SIRT2 (0.54) | SIRT2CYP11B1CYP11B2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | disclosed |
| US-5559113-A | ANTAGONISTS TO HISTAMINE H3 RECEPTORS, SEDATIVES, ANTICONVULSANTS, ANTIULCER AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | 1996-09-24 | — | — | US | disclosed |