Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.68 |
| ▸ | DRD3 | P35462 | 17/20 | 0.68 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972961 | 1.00 | DRD2 (0.68) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7850257 | 0.90 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7853543 | 0.90 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7962871 | 0.88 | DRD3 (0.66) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7976661 | 0.88 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7962866 | 0.88 | DRD3 (0.66) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7976656 | 0.88 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7979204 | 0.86 | DRD2 (0.68) | DRD2DRD3HDAC1HDAC3HDAC6 | |
| SCHEMBL7979208 | 0.86 | DRD2 (0.68) | DRD2DRD3HDAC1HDAC3HDAC6 | |
| SCHEMBL7976527 | 0.86 | DRD2 (0.79) | DRD2DRD3HTR1DHTR1BHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980357-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-23 | — | — | EP | claimed |
| WO-1998050363-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | claimed |
| US-6274593-B1 | TREATING PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA, AND PARKINSON*S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-14 | — | — | US | disclosed |