Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973381 | 0.87 | TLR7 (0.46) | TLR7NUDT1EGFRCSF1RALDH1A1 | |
| SCHEMBL7970274 | 0.74 | TLR7 (0.42) | TLR7CSF1RALDH1A1LMNA | |
| SCHEMBL7941513 | 0.69 | TLR7 (0.56) | TLR7NUDT1TSHR | |
| SCHEMBL21840597 | 0.66 | TDP1 (0.46) | TSHRNPSR1ALDH1A1LMNAKDM4E | |
| SCHEMBL25659408 | 0.66 | TSHR (0.41) | TLR7NUDT1TSHR | |
| SCHEMBL7937354 | 0.64 | KDM4E (0.51) | NOS1CSF1RTSHRNPSR1ALDH1A1 | |
| SCHEMBL27945207 | 0.64 | TSHR (0.55) | TSHRALDH1A1GAAKDM4E | |
| SCHEMBL3023761 | 0.63 | TLR7 (0.50) | TLR7NUDT1TSHR | |
| SCHEMBL8682782 | 0.63 | TSHR (0.46) | TLR7NUDT1TSHRALDH1A1 | |
| SCHEMBL8281042 | 0.62 | MEN1 (0.51) | TSHRNPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | claimed |
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |