Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168411 | 0.73 | MPO (0.54) | MPONUDT1LTB4R | |
| SCHEMBL17538247 | 0.72 | TLR7 (1.00) | TLR7TLR8 | |
| SCHEMBL29556894 | 0.72 | TLR7 (1.00) | TLR7TLR8 | |
| SCHEMBL4747140 | 0.70 | PDPK1 (0.43) | TLR7 | |
| SCHEMBL30107620 | 0.69 | DHFR (0.42) | TLR7MPOTSHR | |
| SCHEMBL7971585 | 0.69 | TLR7 (0.41) | TLR7NUDT1LTB4R | |
| SCHEMBL6377725 | 0.69 | TLR7 (0.42) | TLR7NUDT1TSHRLTB4R | |
| SCHEMBL7973294 | 0.69 | TLR7 (0.47) | TLR7NUDT1TSHR | |
| SCHEMBL7973381 | 0.68 | TLR7 (0.46) | TLR7NUDT1 | |
| SCHEMBL27355403 | 0.68 | PDE5A (0.49) | MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001517226-A | — | — | 2001-10-02 | — | — | JP | claimed |
| EP-0971925-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998043974-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-10-08 | — | — | WO | claimed |