SCHEMBL7973571

SCHEMBL7973571

OCCC[N]Cc1ccncc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.37
NAAA Q02083 1/20 0.36
ALDH1A1 P00352 4/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2D6 P10635 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPT P10636 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HRH1 P35367 2/20 0.34
ALOX15 P16050 1/20 0.34
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33
CCR6 P51684 1/20 0.33
KMT2A Q03164 1/20 0.33
HIF1A Q16665 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10501809 0.79 TDP1 (0.44) ALDH1A1CYP3A4MEN1HPGDKMT2A
SCHEMBL6083210 0.78 LOXL2 (0.50) LOXL2ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL10664385 0.73 TDP1 (0.43) NAAAALDH1A1CYP3A4HPGDTDP1
SCHEMBL10775118 0.72 TDP1 (0.41) NAAAALDH1A1CYP3A4HPGDTDP1
SCHEMBL279761 0.72 HRH1 (0.56) LOXL2NAAAALDH1A1CYP1A2CYP3A4
SCHEMBL6651377 0.71 PLG (0.40) LOXL2NAAAMAPT
SCHEMBL4444401 0.70 HRH1 (0.59) LOXL2NAAAALDH1A1CYP1A2CYP3A4
SCHEMBL26116262 0.70 HRH1 (0.54) LOXL2NAAAALDH1A1CYP1A2CYP3A4
SCHEMBL3157505 0.70 LOXL2 (0.42) LOXL2NAAAALDH1A1CYP1A2CYP3A4
SCHEMBL271114 0.68 HRH1 (0.63) LOXL2NAAAALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001007409-A1 CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS ASTRAZENECA UK LIMITED (GB) 2001-02-01 WO disclosed