Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.74 |
| ▸ | JAK1 | P23458 | 5/20 | 0.66 |
| ▸ | JAK3 | P52333 | 6/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536506 | 0.96 | JAK2 (0.71) | JAK2JAK1JAK3PTK2NPC1 | |
| SCHEMBL7979476 | 0.91 | JAK2 (0.67) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13536706 | 0.91 | JAK2 (0.64) | JAK2JAK1JAK3PTK2TP53 | |
| SCHEMBL13536674 | 0.91 | JAK2 (0.71) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL7979478 | 0.88 | JAK2 (0.67) | JAK2JAK1JAK3PTK2NPC1 | |
| SCHEMBL7977754 | 0.86 | JAK2 (0.72) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7964178 | 0.86 | JAK2 (0.81) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL3213555 | 0.85 | JAK2 (1.00) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7974770 | 0.85 | JAK2 (0.71) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL13536667 | 0.85 | JAK2 (0.64) | JAK2JAK1JAK3PTK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |