Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.64 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PRKX | P51817 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536674 | 0.94 | JAK2 (0.71) | JAK2JAK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL13536675 | 0.90 | JAK1 (0.72) | JAK2JAK1LMNAHTTSMN1; SMN2 | |
| SCHEMBL13536507 | 0.90 | JAK2 (0.61) | JAK2JAK1JAK3PTK2MAPK14 | |
| SCHEMBL13536527 | 0.89 | JAK2 (0.62) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13536579 | 0.87 | JAK2 (0.60) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13536506 | 0.87 | JAK2 (0.71) | JAK2JAK1GSK3BJAK3PTK2 | |
| SCHEMBL13536528 | 0.86 | JAK2 (0.61) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13536707 | 0.85 | LMNA (0.57) | JAK2JAK1JAK3PTK2LMNA | |
| SCHEMBL7973589 | 0.85 | JAK2 (0.74) | JAK2JAK1GSK3BJAK3PTK2 | |
| SCHEMBL13536706 | 0.83 | JAK2 (0.64) | JAK2JAK1MMP13ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |