Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 18/20 | 0.74 |
| ▸ | GRIA2 | P42262 | 18/20 | 0.74 |
| ▸ | GRIA3 | P42263 | 18/20 | 0.74 |
| ▸ | GRIA4 | P48058 | 18/20 | 0.74 |
| ▸ | GRIK1 | P39086 | 12/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 12/20 | 0.69 |
| ▸ | GRIK3 | Q13003 | 12/20 | 0.69 |
| ▸ | GRIK4 | Q16099 | 12/20 | 0.69 |
| ▸ | GRIK5 | Q16478 | 12/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609391 | 0.93 | GRIA1 (0.80) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8609084 | 0.89 | GRIA1 (0.81) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8609954 | 0.88 | GRIA1 (0.78) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8610465 | 0.88 | GRIA1 (0.73) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL24312933 | 0.88 | GRIA1 (0.77) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7665861 | 0.85 | GRIA1 (0.78) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7479847 | 0.85 | GRIA1 (0.68) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7668608 | 0.83 | GRIA1 (0.78) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8612870 | 0.83 | GRIA1 (0.75) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8612872 | 0.83 | GRIA1 (0.75) | GRIA1GRIA2GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277850-B1 | EFFICIENCY, BIOCOMPATIBILITY, TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ABBOTT LABORATORIES | 2001-08-21 | — | — | US | disclosed |
| US-5849743-A | Quinoxalines and drugs prepared therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| WO-1996019476-A1 | NOVEL QUINOXALINES AND DRUGS PREPARED THEREFROM | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-27 | — | — | WO | disclosed |