Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7186951 | 0.90 | PDE4A (0.53) | KDM4EALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL7167976 | 0.87 | PDE4A (0.59) | KMT2AMEN1PDE4AKCNH2TP53 | |
| SCHEMBL7172242 | 0.87 | PDE4A (0.59) | PDE4AKCNH2TP53MAPT | |
| SCHEMBL7602515 | 0.86 | PDE4A (0.60) | KDM4ELMNAPDE4AKCNH2 | |
| SCHEMBL7192794 | 0.85 | LMNA (0.53) | HPGDLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7684539 | 0.85 | PDE4A (0.59) | KDM4EALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL7169239 | 0.84 | PDE4A (0.57) | KDM4ENPC1RAB9APDE4AKCNH2 | |
| SCHEMBL7172238 | 0.83 | PDE4A (0.56) | KDM4ENPC1RAB9APDE4AKCNH2 | |
| SCHEMBL7185413 | 0.82 | PDE4A (0.65) | KDM4EALDH1A1HPGDPDE4AKCNH2 | |
| SCHEMBL7169646 | 0.82 | PDE4A (0.62) | NPC1RAB9APDE4AKCNH2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297248-B1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LIMITED (JP) | 2001-10-02 | — | — | US | disclosed |