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SCHEMBL7974315

SCHEMBL7974315

CC(C)(C)OC(=O)N1CCC(Cn2cncc2Cc2ccc(C#N)cc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.48
▸ FNTA P49354 8/20 0.48
▸ FNTB P49356 8/20 0.48
▸ PGGT1B P53609 6/20 0.45
▸ CYP11B1 P15538 2/20 0.43
▸ CYP11B2 P19099 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3146175 0.79 GPR119 (0.60) GPR119
SCHEMBL7974242 0.78 FNTA (0.63) FNTAFNTBPGGT1B
SCHEMBL20015578 0.78 GPR119 (0.59) GPR119
Hydrochloric Acid SCHEMBL7972916 0.78 FNTA (0.62) FNTAFNTBPGGT1B
SCHEMBL7831743 0.77 FNTA (0.64) FNTAFNTBPGGT1B
SCHEMBL7838564 0.77 CYP11B1 (0.48) FNTAFNTBPGGT1BCYP11B1CYP11B2
SCHEMBL7839628 0.76 FNTA (0.45) FNTAFNTBPGGT1BCYP11B1CYP11B2
Hydrochloric Acid SCHEMBL7972613 0.76 FNTA (0.64) FNTAFNTBPGGT1B
SCHEMBL1575722 0.76 GPR119 (0.57) GPR119
Hydrochloric Acid SCHEMBL7974608 0.76 FNTA (0.45) FNTAFNTBPGGT1BCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248756-B1 Inhibitors of farnesyl-protein transferase MERCK & CO., INC. 2001-06-19 — — US disclosed
US-5891889-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1999-04-06 — — US disclosed