Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 7/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871373 | 1.00 | HRH4 (0.44) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL18402529 | 0.97 | HRH4 (0.48) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL859796 | 0.92 | SIGMAR1 (0.45) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL18402586 | 0.92 | HRH4 (0.50) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL20834976 | 0.90 | HRH4 (0.44) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL20835000 | 0.89 | HRH4 (0.50) | HRH4HRH3ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL2696234 | 0.86 | KCNH2 (0.47) | HRH4HRH3ALDH1A1KCNH2LMNA | |
| SCHEMBL674217 | 0.86 | KCNH2 (0.47) | HRH4HRH3ALDH1A1KCNH2LMNA | |
| SCHEMBL2696007 | 0.86 | KCNH2 (0.47) | HRH4HRH3ALDH1A1KCNH2LMNA | |
| SCHEMBL2697514 | 0.86 | KCNH2 (0.47) | HRH4HRH3ALDH1A1KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549983-B2 | Amine cationic lipids and uses thereof | DICERNA PHARMACEUTICALS, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | disclosed |
| US-5559113-A | ANTAGONISTS TO HISTAMINE H3 RECEPTORS, SEDATIVES, ANTICONVULSANTS, ANTIULCER AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | 1996-09-24 | — | — | US | disclosed |