Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12327101 | 0.83 | TSHR (0.52) | TSHRSRD5A2KMOPOLBHPGD | |
| SCHEMBL7964353 | 0.80 | TSHR (0.47) | TSHRSRD5A2KMOPOLBHPGD | |
| SCHEMBL16450946 | 0.79 | TSHR (0.49) | TSHRHPGDHTT | |
| SCHEMBL7964529 | 0.76 | TSHR (0.55) | TSHRSRD5A2KMOPOLBHPGD | |
| SCHEMBL7977976 | 0.75 | TSHR (0.38) | TSHRSRD5A2KMOPOLBHPGD | |
| SCHEMBL12327098 | 0.75 | TSHR (0.44) | TSHRSRD5A2KMOPOLBHPGD | |
| SCHEMBL7980416 | 0.75 | L3MBTL1 (0.58) | TSHRPOLBHPGDHTT | |
| SCHEMBL7973976 | 0.74 | SLC6A4 (0.56) | TSHRPOLBHPGDHTT | |
| SCHEMBL12327067 | 0.71 | HDAC4 (0.41) | TSHRSRD5A2MAOAMAOBPOLB | |
| SCHEMBL7964755 | 0.71 | TSHR (0.40) | TSHRSRD5A2KMOPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | disclosed |