Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19227456 | 0.83 | POLB (0.71) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL5884747 | 0.82 | SYK (0.70) | MEN1KMT2ASYKPOLBCYP2D6 | |
| SCHEMBL3426969 | 0.80 | SYK (0.59) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL17537447 | 0.80 | SYK (0.59) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL14578262 | 0.80 | SYK (0.59) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL14577958 | 0.80 | POLB (0.59) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL22337384 | 0.79 | SYK (0.58) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL19224090 | 0.78 | MEN1 (0.57) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL348153 | 0.77 | MEN1 (0.59) | MEN1KMT2ASYKPOLBNPC1 | |
| SCHEMBL14694091 | 0.76 | LMNA (0.64) | KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |