Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846339 | 0.88 | MAPT (0.68) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL10542066 | 0.84 | ALDH1A1 (0.55) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL5156571 | 0.84 | SMN1; SMN2 (0.67) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL2031092 | 0.83 | KCNK2 (0.64) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL3694733 | 0.81 | MAPT (0.77) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL9681603 | 0.81 | ALDH1A1 (0.63) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL12703765 | 0.81 | KMT2A (0.61) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL8553107 | 0.81 | GRIK1 (0.60) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL14574207 | 0.81 | MAPT (0.55) | ALDH1A1CYP3A4ALOX15TDP1MAPT | |
| SCHEMBL1663739 | 0.81 | MAPT (0.56) | ALDH1A1CYP3A4ALOX15TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |