Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 13/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961536 | 0.89 | ADK (0.69) | ADKMAP4K4KDM4EPOLBPPARG | |
| SCHEMBL7971554 | 0.88 | ADK (0.74) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL7974716 | 0.87 | ADK (0.76) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL8153484 | 0.86 | ADK (0.83) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL7961356 | 0.85 | ADK (0.78) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL7973133 | 0.84 | ADK (0.62) | ADKMAP4K4 | |
| SCHEMBL7974777 | 0.83 | ADK (0.78) | ADKMAP4K4 | |
| SCHEMBL7974874 | 0.83 | ADK (0.77) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL7974673 | 0.82 | ADK (0.60) | ADKKDM4EPOLBPPARGMCL1 | |
| SCHEMBL7961360 | 0.82 | ADK (0.66) | ADKKDM4EPOLBPPARGMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057040-A1 | 6,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057040-A1 | 6,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |
| EP-0979230-A1 | 6,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | Abbott Laboratories (US) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998046603-A1 | 6,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 1998-10-22 | — | — | WO | disclosed |