Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.56 |
| ▸ | TYMP | P19971 | 2/20 | 0.55 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975005 | 0.95 | TYMP (0.55) | ADORA3TYMPDNPH1TP53SLC29A1 | |
| SCHEMBL7961549 | 0.95 | TYMP (0.51) | ADORA3TYMPDNPH1TP53SLC29A1 | |
| SCHEMBL27028364 | 0.91 | TYMP (0.56) | TYMP | |
| SCHEMBL27135325 | 0.91 | TYMP (0.56) | TYMP | |
| SCHEMBL1389413 | 0.85 | ADORA3 (0.64) | ADORA3DNPH1TP53SLC29A1TDP1 | |
| SCHEMBL30689461 | 0.85 | TYMP (0.58) | TYMP | |
| SCHEMBL918538 | 0.84 | TYMP (0.55) | TYMPDNPH1 | |
| SCHEMBL918537 | 0.84 | TYMP (0.55) | TYMPDNPH1 | |
| SCHEMBL21750464 | 0.84 | TYMP (0.51) | TYMPNT5EP2RX3P2RX2 | |
| SCHEMBL21750463 | 0.84 | TYMP (0.51) | TYMPNT5EP2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281201-B1 | REPLACEMENT OF THE ADENINE MOIETY IN THE (2'-5')OLIGOADENYLATE TRIMER CORE WITH 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE OR WITH N6-(BENZYLAMINO)PURINE (ADEBN)-MOIETIES HAS RESULTED IN A NEW GROUP OF INHIBITORS OF HIV-1 REPLICATION. | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2001-08-28 | — | — | US | disclosed |