Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | F9 | P00740 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | F11 | P03951 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 11/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307778 | 0.91 | HDAC6 (0.57) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7970994 | 0.84 | HDAC6 (0.59) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10139860 | 0.83 | F9 (0.69) | CHEK1F9F10F11F7 | |
| SCHEMBL7959397 | 0.82 | CHEK2 (0.68) | F9F10F11F7CHEK2 | |
| SCHEMBL7972717 | 0.80 | F9 (0.77) | CHEK1F9F10F11F7 | |
| SCHEMBL10172686 | 0.80 | CHEK2 (0.69) | F9F10F11F7CHEK2 | |
| SCHEMBL10139859 | 0.77 | CHEK2 (0.64) | F9F10F11F7CHEK2 | |
| SCHEMBL10139999 | 0.76 | HDAC6 (0.54) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18229535 | 0.76 | HDAC6 (0.98) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20307772 | 0.76 | F9 (0.64) | F9F10F11F7CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |