Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 19/20 | 0.68 |
| ▸ | F9 | P00740 | 1/20 | 0.64 |
| ▸ | F10 | P00742 | 1/20 | 0.64 |
| ▸ | F11 | P03951 | 1/20 | 0.64 |
| ▸ | F7 | P08709 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139860 | 0.93 | F9 (0.69) | CHEK2F9F10F11F7 | |
| SCHEMBL7972721 | 0.90 | CHEK2 (0.67) | CHEK2F9F10F11F7 | |
| SCHEMBL10172686 | 0.89 | CHEK2 (0.69) | CHEK2F9F10F11F7 | |
| SCHEMBL7972717 | 0.89 | F9 (0.77) | CHEK2F9F10F11F7 | |
| SCHEMBL20307772 | 0.89 | F9 (0.64) | CHEK2F9F10F11F7 | |
| SCHEMBL10139859 | 0.87 | CHEK2 (0.64) | CHEK2F9F10F11F7 | |
| SCHEMBL20307778 | 0.83 | HDAC6 (0.57) | CHEK2F9F10F11F7 | |
| SCHEMBL7978282 | 0.83 | CHEK2 (0.56) | CHEK2F9F10F11F7 | |
| SCHEMBL7974939 | 0.82 | HDAC6 (0.59) | CHEK2F9F10F11F7 | |
| SCHEMBL7972817 | 0.81 | F9 (0.54) | CHEK2F9F10F11F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |