SCHEMBL7975156

SCHEMBL7975156

c1ccc(-c2nc3ccccn3c2NC2CCCCC2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 1/20 0.81
ALOX5 P09917 5/20 0.71
BRD4 O60885 1/20 0.69
ALDH1A1 P00352 3/20 0.68
GAA P10253 2/20 0.68
KDM4E B2RXH2 2/20 0.68
GFER P55789 1/20 0.68
TRIM33 Q9UPN9 3/20 0.68
MAPT P10636 1/20 0.67
MAPK1 P28482 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
ROCK2 O75116 1/20 0.67
PIM1 P11309 1/20 0.67
GSK3B P49841 1/20 0.67
AURKB Q96GD4 1/20 0.67
TRIM24 O15164 2/20 0.64
CYP1A2 P05177 1/20 0.63
CYP3A4 P08684 1/20 0.63
CYP2D6 P10635 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2986663 0.99 ADORA1 (0.79) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL7977482 0.91 ADORA1 (0.76) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL2977991 0.90 ADORA1 (1.00) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL15152601 0.90 ADORA1 (0.78) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL1967978 0.90 ADORA1 (0.78) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL1965852 0.90 ADORA1 (0.78) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL1965930 0.90 ADORA1 (0.78) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL2977837 0.88 ADORA1 (0.76) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL1965379 0.88 ADORA1 (0.76) ADORA1ALOX5BRD4ALDH1A1GAA
SCHEMBL15152579 0.88 ADORA1 (0.76) ADORA1ALOX5BRD4ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116102548-A Cu-W 2 Method for preparing imidazole pyridine compound by using C/AC catalytic lignin and beta-O-4 model compound 中国科学院大连化学物理研究所 2023-05-12 CN claimed
WO-2001027119-A2 SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES Grünenthal GmbH (DE) 2001-04-19 WO claimed
CN-116102548-A Cu-W 2 Method for preparing imidazole pyridine compound by using C/AC catalytic lignin and beta-O-4 model compound 中国科学院大连化学物理研究所 2023-05-12 CN disclosed
WO-2009027077-A2 5-ARYLALKYLIDENE-2-ARYLALKYL-THIAZOL-4-ONE DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE AND USES THEREOF JOHANN WOLFGANG GOETHE-UNIVERSITÄT, FRANKFURT AM MAIN (DE) 2009-03-05 WO disclosed
WO-2001027119-A2 SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES Grünenthal GmbH (DE) 2001-04-19 WO disclosed