Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 13/20 | 0.70 |
| ▸ | MAPT | P10636 | 10/20 | 0.70 |
| ▸ | HTT | P42858 | 7/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.66 |
| ▸ | GFER | P55789 | 2/20 | 0.65 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643651 | 0.83 | ADRA1B (0.67) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4502584 | 0.83 | GAA (0.58) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4490753 | 0.82 | GAA (0.57) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7977337 | 0.82 | TOP2A (0.69) | GAAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6652164 | 0.81 | GAA (0.71) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL13905567 | 0.79 | BRD4 (0.72) | GAAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4476462 | 0.77 | NR1H4 (0.68) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL6651229 | 0.77 | GAA (0.71) | GAAMAPTSMN1; SMN2TP53MAPK1 | |
| Hydrochloric Acid SCHEMBL4495467 | 0.76 | NR1H4 (0.67) | GAAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5121668 | 0.76 | GAA (0.43) | GAAMAPTHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027119-A2 | SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |