Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194951 | 0.94 | CYP2D6 (0.72) | CYP2D6ALOX5HTTCYP2C9CYP2C19 | |
| Water SCHEMBL3089403 | 0.93 | CYP2D6 (0.70) | CYP2D6ALOX5HTTCYP2C9CYP2C19 | |
| SCHEMBL8018069 | 0.81 | CYP2D6 (0.53) | CYP2D6HTTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7972839 | 0.81 | CYP2D6 (0.53) | CYP2D6HTTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7972123 | 0.80 | CYP2D6 (0.52) | CYP2D6HTTSMN1; SMN2MAPT | |
| SCHEMBL14590778 | 0.79 | HTT (0.65) | CYP2D6HTTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7968909 | 0.78 | CYP2D6 (0.50) | CYP2D6HTTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL9191980 | 0.78 | CYP2D6 (0.75) | CYP2D6CYP2C9CYP2C19CCNA2CDK2 | |
| SCHEMBL14817973 | 0.78 | CYP2D6 (0.65) | CYP2D6HTTPOLBGAA | |
| SCHEMBL7972482 | 0.77 | CYP2D6 (0.49) | CYP2D6HTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0968201-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998035951-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-20 | — | — | WO | disclosed |