Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252382 | 0.92 | CDK2 (0.42) | INSRIGF1RCDK2SYKPLK1 | |
| SCHEMBL7976853 | 0.91 | CDK2 (0.42) | INSRIGF1REGFRERBB2CDK2 | |
| SCHEMBL10252007 | 0.88 | IGF1R (0.45) | INSRIGF1REGFRERBB2CDK2 | |
| SCHEMBL7974320 | 0.85 | IGF1R (0.42) | IGF1REGFRERBB2CDK2PLK1 | |
| SCHEMBL701224 | 0.84 | IGF1R (0.47) | INSRIGF1REGFRERBB2SYK | |
| SCHEMBL7963827 | 0.82 | CCNT1 (0.51) | INSRIGF1RCDK2IKBKBCHUK | |
| SCHEMBL7974201 | 0.82 | IGF1R (0.46) | INSRIGF1REGFRERBB2CDK2 | |
| SCHEMBL7980921 | 0.80 | CDK2 (0.43) | CDK2KCNH2JAK2JAK1JAK3 | |
| SCHEMBL700320 | 0.80 | HDAC1 (0.53) | INSRIGF1REGFRERBB2JAK2 | |
| SCHEMBL13498475 | 0.80 | SYK (0.40) | INSRIGF1RCDK2SYKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |