Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963827 | 0.93 | CCNT1 (0.51) | IGF1RCCNT1CDK9AURKAINSR | |
| SCHEMBL701224 | 0.92 | IGF1R (0.47) | IGF1RSYKCCNT1CDK9INSR | |
| SCHEMBL10252086 | 0.90 | SYK (0.43) | SYKCCNT1CDK9AURKAINSR | |
| SCHEMBL7976848 | 0.87 | CDK2 (0.53) | IGF1RSYKCCNT1CDK9AURKA | |
| SCHEMBL7965204 | 0.86 | CDK2 (0.54) | IGF1RSYKAURKAINSRSRC | |
| SCHEMBL700320 | 0.85 | HDAC1 (0.53) | IGF1RINSRABL1EGFRERBB2 | |
| SCHEMBL7975185 | 0.82 | INSR (0.42) | IGF1RSYKINSREGFRERBB2 | |
| SCHEMBL10251986 | 0.81 | CCNT1 (0.46) | SYKCCNT1CDK9AURKAKMT2A | |
| SCHEMBL699814 | 0.80 | CDK2 (0.51) | IGF1RCCNT1CDK9PTK2CAMK2D | |
| SCHEMBL10252084 | 0.80 | CAMK2D (0.48) | ABL1BCRKMT2ACAMK2DCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |