SCHEMBL7975271

SCHEMBL7975271

O=c1nc(-c2ccccc2)[nH]c2ncn(Cc3ccccc3)c12

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNOT7 Q9UIV1 5/20 0.56
PARN O95453 1/20 0.56
PNP P00491 2/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.44
ADORA3 P0DMS8 1/20 0.43
ADORA2B P29275 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
KMT2A Q03164 1/20 0.43
CXCR2 P25025 1/20 0.42
BRD4 O60885 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7991406 0.93 CNOT7 (0.49) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7975135 0.93 CNOT7 (0.52) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7984461 0.93 CNOT7 (0.52) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7974444 0.93 CNOT7 (0.52) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7988562 0.92 CNOT7 (0.54) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7974508 0.92 CNOT7 (0.51) CNOT7PARNPNPSMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL7985519 0.92 CNOT7 (0.51) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7984720 0.92 CNOT7 (0.48) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7986522 0.92 CNOT7 (0.48) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7988669 0.91 PARN (0.48) CNOT7PARNPNPSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310070-B1 FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS JAPAN ENERGY CORPORATION (JP) 2001-10-30 US disclosed
EP-0999211-A1 NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF JAPAN ENERGY CORPORATION (JP) 2000-05-10 EP disclosed