Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | FAP | Q12884 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL921182 | 0.87 | DPP4 (0.47) | DPP4CYP3A4CYP2D6CYP1A2FAP | |
| SCHEMBL14422123 | 0.79 | DPP4 (0.53) | DPP4CYP3A4CYP2D6CYP1A2KCNH2 | |
| SCHEMBL3899419 | 0.75 | DPP4 (0.45) | DPP4KCNH2 | |
| SCHEMBL7978524 | 0.74 | DPP4 (0.75) | DPP4CYP3A4CYP2D6CYP1A2FAP | |
| SCHEMBL3899886 | 0.74 | DPP4 (0.47) | DPP4FAPKCNH2 | |
| SCHEMBL7978548 | 0.74 | ALDH1A1 (0.35) | DPP4CYP3A4CYP1A2FAP | |
| SCHEMBL3898788 | 0.72 | DPP4 (0.44) | DPP4FAP | |
| SCHEMBL13647359 | 0.71 | DPP4 (0.57) | DPP4CYP3A4CYP2D6CYP1A2FAP | |
| SCHEMBL3905904 | 0.71 | DPP4 (0.45) | DPP4KCNH2 | |
| SCHEMBL13647462 | 0.71 | DPP4 (0.45) | DPP4FAPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264034-A1 | BICYCLIC PYRROLE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009128360-A1 | THERAPEUTIC AGENT FOR DIABETES | 大日本住友製薬株式会社 (JP) | 2009-10-22 | — | — | WO | disclosed |