Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 2/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27442056 | 0.85 | GALR3 (0.47) | TNFKDM4EALDH1A1HTR6MEN1 | |
| SCHEMBL22533595 | 0.85 | DCTPP1 (0.56) | TNFKDM4EALDH1A1HTR6MEN1 | |
| SCHEMBL1701199 | 0.82 | TNF (0.60) | TNFKDM4EALDH1A1HTR6MAPT | |
| SCHEMBL7978785 | 0.81 | TLR8 (0.52) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL28076729 | 0.81 | TNF (0.59) | TNFKDM4EALDH1A1HTR6MEN1 | |
| Formic Acid SCHEMBL28717019 | 0.80 | DCTPP1 (0.51) | TNFKDM4EALDH1A1HTR6MEN1 | |
| SCHEMBL28076959 | 0.79 | TNF (0.57) | TNFKDM4EALDH1A1HTR6MEN1 | |
| SCHEMBL3164934 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL16372380 | 0.78 | DCTPP1 (0.51) | TNFKDM4EALDH1A1HTR6MEN1 | |
| SCHEMBL7965582 | 0.77 | TNF (0.55) | TNFHTR6MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115108994-B | Tergolian intermediate and preparation method and application thereof | 江苏威奇达药业有限公司 | 2024-05-31 | — | — | CN | claimed |
| CN-115108994-A | Tegolrazan intermediate and preparation method and application thereof | 江苏威奇达药业有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-115108994-B | Tergolian intermediate and preparation method and application thereof | 江苏威奇达药业有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-115108994-A | Tegolrazan intermediate and preparation method and application thereof | 江苏威奇达药业有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-6194396-B1 | ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-27 | — | — | US | disclosed |
| US-6083961-A | FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0774462-A1 | HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |